Study Links Salmonella Exposure to Colon Cancer Risk.
A new study , published by the publication Cell Reports Medicine connects the exposure to salmonella bacteria with the risk of colon cancer.
Researchers, which includes a team led by Jun Sun from the University of Illinois Chicago conducted research on human colon cancer samples and animal models . They discovered the exposure to salmonella was associated with colon cancers which developed earlier and became larger.
The study’s authors initially looked at the results of a retrospective study of patients with colon cancer who found that the tissue samples taken in routine colon cancer surgery that contained salmonella antibodies were more likely to be taken from patients who suffered from the worst colon cancer outcomes.
By using Salmonella isolates from sample tissues Sun as well as her U.S.-based team examined mice suffering from colon cancer who were subjected to bacteria. They noticed an increase in tumor size and bigger tumors in mice exposed to exposure to salmonella. The researchers also noticed an increase in salmonella that was transferred to tumors.
“During illness, salmonella interferes with vital signaling pathways in the host, and these molecular modifications could result in the transformation of cancerous cells.
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This study reveals that we need to conduct more research in order to understand the relationship between the exposure to salmonella and the risk of colon cancer in the USA and that by preparing food in a safe manner could help in securing ourselves” said Dr. Sun Sun, UIC professor of medicine.
Sun’s collaborators from the Netherlands have also examined the bacteria in the lab in vitro. They mingled Precancerous human cells as well as cancerous ones to study the Salmonella strain inside the laboratory and monitored any changes or growth within the tumor.
They found that just one infection could cause transformation , and every salmonella infection dramatically increased the rate of cell transformation.
“The tissues and mouse tests reveal that salmonella-related infections had an ongoing effect that accelerated the growth of tumors,” said Sun, who is also a member of the University of Illinois Cancer Center at UIC.
“This research suggests that we should investigate the issue of salmonella exposure as a risk factor in the environment for chronic diseases like colon cancer.”